Barbiturates and oxidative phosphorylation

Barbiturates and oxidative phosphorylation.

It has been claimed that barbiturates uncouple oxidative phosphorylations (Brody & Bain, 1954; Brody, 1955). These authors have demonstrated that during the oxidation of pyruvate by liver and brain mitochondria, phosphate uptake was lowered proportionately more than oxygen uptake. Support for the uncoupling theory was derived from certain similarities between the barbiturates and 2:4dinitrophen...

Barbiturates.

Vitamin K and oxidative phosphorylation.

1. Oxidative phosphorylation was studied in a cell-free preparation of Mycobacterium phlei and in rat-liver mitochondria. Phosphorylation was destroyed in both systems by long-wave ultraviolet radiation and restored by the addition of small amounts of [2-Me-(14)C,(3)H]phylloquinone. When the radioactive quinones were recovered from the phosphorylating system and chromatographed with carrier phy...

Electron Transport and Oxidative Phosphorylation

Objectives: I. Describe the structure of the Mitochondrion. A. Compare the structure of the outer membrane to the structure of the inner membrane. B. What metabolic pathways are localized to the mitochondrion? 1. Where in the mitochondrion are they located? II. What is(are) the overall chemical reaction(s) of electron transport and oxidative phosphorylation? III. Describe the overall makeup of ...

Oxidative phosphorylation and lacunar stroke